IFRA 57 Allergens in Fragrance Materials Using GC-MS with Hydrogen Carrier Gas

The International Fragrance Association (IFRA) sets global safety standards for fragrance ingredients, including the “IFRA 57 Allergens” list, which identifies compounds requiring monitoring for consumer safety and compliance. Gas Chromatography–Mass Spectrometry (GC-MS) is widely used to detect and quantify these allergens with high accuracy. This application note demonstrates how SCION Instruments GC-MS meets IFRA 57 requirements, achieving reliable detection above 2 mg/kg. Using the FFNSC 3 spectral library, the system also supports fragrance screening and profiling. The method employs a hydrogen carrier gas, offering a sustainable alternative to helium while maintaining analytical performance.

Key learnings from this application note:

  1. Learn how the SCION Instruments GC-MS equipped with specialist application column, SLB-IL60i, was able to consolidate the testing for the stringent requirements of the IFRA 57 Allergens method into a single run and post processing method, greatly improving sample output. 
  2. Helium is in short supply and is expensive, discover how this application achieved regulatory compliance using hydrogen as a carrier gas with the SCION Instruments Helium Free field kit.

Download this Application Note – IFRA 57 Allergens in Fragrance Materials Using GC-MS with Hydrogen Carrier Gas